WEGOVY INJECTION

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On August 26, 2021

Wegovy is a GLP-1 agonist. It is used for weight loss in people with obesity or who are overweight and have certain other health conditions, to reduce the risk of major cardiovascular events such as death, heart attack, or stroke in people with either obesity or overweight, and to treat a liver disease called metabolic dysfunction-associated steatohepatitis (MASH). Nausea, vomiting, diarrhea, constipation, stomach (abdomen) pain, bloating, and upset stomach are among the most common side effects.

Wegovy is a prescription-only injectable medicine containing semaglutide, primarily used for chronic weight management in adults and adolescents aged 12 and older. It works by mimicking the GLP-1 hormone, which regulates appetite in the brain and slows stomach emptying, helping users feel full longer.

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What is Wegovy used for?

Wegovy (semaglutide) is commonly used for the following conditions.

Weight loss in people who are obese or who are overweight and have other health conditions, such as high blood pressure, diabetes, or high cholesterol
To lower the risk of cardiovascular events (heart attack, stroke, or death) in people who have heart disease and are either overweight or obese
A liver disease called metabolic dysfunction-associated steatohepatitis (MASH), which was previously called nonalcoholic steatohepatitis (NASH) (injection only)

Learn more about the dual benefits of Wegovy for weight management and heart health.

Navigating MASH: What to Know About Wegovy for Fatty Liver Disease

Wegovy may also be used for other conditions as determined by your health care provider.

How does Wegovy work (mechanism of action)?

Wegovy works for weight loss by reducing appetite and slowing down the movement of food through your body. Weight loss from Wegovy can lead to improved cardiovascular risk factors, such as decreased blood pressure, improved cholesterol levels, and better control of blood sugar. In people with MASH, fat builds up in the liver causing inflammation. Weight loss helps reduce fat in the liver, potentially reducing inflammation and scarring.

How is Wegovy supplied (dosage forms)?

Wegovy is available as 1.5 mg, 4 mg, 9 mg, and 25 mg oral tablets that are swallowed and in the following dosage forms that are injected under the skin.

0.25 mg solution for injection, prefilled pens
0.5 mg solution for injection, prefilled pens
1 mg solution for injection, prefilled pens
1.7 mg solution for injection, prefilled pens
2.4 mg solution for injection, prefilled pens

WEGOVY . How should I store Wegovy?

Injection Liquid. Wegovy injection liquid should be stored in its original carton in the refrigerator, between 36 F to 46 F (2 C to 8 C). Unused Wegovy can be stored until the expiration date. If needed (as long as the cap has not been removed), Wegovy can be stored at higher temperatures, between 46 F to 86 F (8 C to 30 C), for up to 28 days. Store in a place that is not exposed to direct light and heat. Do not freeze.

Oral Tablet. Wegovy tablets should be stored in their original container at room temperature, between 68 F and 77 F (20 C and 25 C). It can be exposed to temperatures between 59 F and 86 F (15 C and 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.

Side Effects

What are the most common side effects of Wegovy?

The most common side effects of Wegovy are listed below. Tell your health care provider if you have any of these side effects that bother you.

Nausea/vomiting
Diarrhea/constipation
Stomach pain, upset stomach or indigestion, acid reflux
Headache
Tiredness
Dizziness
Swelling of your stomach area
Low blood sugar (in people with diabetes)
Gas or burping
Stomach flu
Infection in the nose or throat, sore throat, or common cold symptoms

There may be other side effects of Wegovy that are not listed here. Contact your health care provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.