What it is

Adamax is a synthetic ACTH(4-10) analog peptide developed as a structurally modified derivative of Semax. The Semax core sequence (Met-Glu-His-Phe-Pro-Gly-Pro) is acetylated at the N-terminus and incorporates an adamantyl group — modifications that extend plasma half-life from minutes to several hours and improve blood-brain barrier penetration relative to unmodified Semax. Supplied as a sterile lyophilized powder with documented purity specifications. Suitable for in vitro investigations of BDNF/TrkB signaling, MC4 receptor pharmacology, and CNS neuropeptide structure-activity research.

Purity: ≥99% (HPLC)
Form: Sterile lyophilized powder
Storage: -20°C, protect from light and moisture
Reconstitution: Bacteriostatic water (BAC water) or appropriate buffer
Stability: 24+ months as supplied; reconstituted solutions stored at 2–8°C and used within 30 days
Sequence: N-Acetyl-Semax (Ac-MEHFPGP) with adamantyl modification

Supplied as a lyophilized powder and sealed against light and moisture — shelf-stable, no cold chain required. Every lot is assayed by an independent laboratory and the certificate is published before the compound is listed. Strictly for in-vitro laboratory research.

Research applications

BDNF expression and TrkB receptor sensitization studies in hippocampal and cortical models
MC4 receptor pharmacology and ACTH(4-10) analog signaling research
Long-term potentiation (LTP) and synaptic plasticity investigation
Cognitive function and learning/memory research models
Neuroprotection and oxidative stress response studies
Extended-half-life CNS peptide pharmacokinetic characterization

Storage & handling

Handle under aseptic conditions in accordance with laboratory safety protocols. Lyophilized material should be stored at -20°C protected from light and moisture. Reconstitute by injecting bacteriostatic water (BAC water) slowly along the vial wall and swirling gently — do not vortex. Once reconstituted, store at 2–8°C and use within 30 days; aliquot to avoid repeated freeze-thaw cycles. Refer to the Certificate of Analysis (CoA) for batch-specific handling recommendations. For laboratory research use only — not for human consumption, veterinary use, or food and drug applications.

Research notes

What is the intended use of this compound? For laboratory research use only. Not for human or veterinary use.
Is a Certificate of Analysis available? Yes, each lot is supplied with a CoA documenting purity and identity confirmation by independent third-party HPLC and mass spectrometry.
What reconstitution buffer is recommended? Bacteriostatic water (BAC water) is the most commonly referenced solvent in published Semax-family research protocols. Sterile water or appropriate buffer may also be used depending on the experimental design.
How does Adamax differ from Semax? Adamax adds N-acetylation and an adamantyl modification to the Semax (MEHFPGP) core, extending plasma half-life from minutes to several hours and improving blood-brain barrier penetration in research models.
Can this be used in cell culture experiments? Yes, when properly reconstituted and diluted under sterile conditions for in vitro applications.