What it is

Kisspeptin-10 is a 10-amino-acid neuropeptide (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) and the bioactive C-terminal fragment of kisspeptin-54, encoded by the KISS1 gene. As a high-affinity agonist of the GPR54 (KISS1R) receptor, it serves as a primary tool compound for hypothalamic-pituitary-gonadal (HPG) axis research, driving pulsatile GnRH secretion and downstream LH/FSH regulation. Supplied as a sterile lyophilized powder with documented purity specifications. Suitable for in vitro investigations of GPR54 receptor binding, GnRH neuronal activity, and reproductive endocrinology research.

Purity: ≥99% (HPLC)
Form: Sterile lyophilized powder
Storage: -20°C, protect from light and moisture
Reconstitution: Bacteriostatic water (BAC water) or appropriate buffer
Stability: 24+ months as supplied; reconstituted solutions stored at 2–8°C and used within 30 days
Molecular Weight: 1,302.5 Da (10 amino acids)

Supplied as a lyophilized powder and sealed against light and moisture — shelf-stable, no cold chain required. Every lot is assayed by an independent laboratory and the certificate is published before the compound is listed. Strictly for in-vitro laboratory research.

Research applications

GPR54 (KISS1R) receptor binding and signal transduction studies
HPG axis modulation and GnRH pulse dynamics research
LH and FSH regulation and gonadotropin feedback investigation
Metabolic-reproductive crosstalk research (leptin, insulin, energy homeostasis)
Neuroprotection and CNS kisspeptin signaling models
Tumor suppression and metastatic signaling research (KISS1 metastasis suppressor)

Storage & handling

Handle under aseptic conditions in accordance with laboratory safety protocols. Lyophilized material should be stored at -20°C protected from light and moisture. Reconstitute by injecting bacteriostatic water (BAC water) slowly along the vial wall and swirling gently — do not vortex. Once reconstituted, store at 2–8°C and use within 30 days; aliquot to avoid repeated freeze-thaw cycles. Refer to the Certificate of Analysis (CoA) for batch-specific handling recommendations. For laboratory research use only — not for human consumption, veterinary use, or food and drug applications.

Research notes

What is the intended use of this compound? For laboratory research use only. Not for human or veterinary use.
Is a Certificate of Analysis available? Yes, each lot is supplied with a CoA documenting purity and identity confirmation by independent third-party HPLC and mass spectrometry.
What reconstitution buffer is recommended? Bacteriostatic water (BAC water) is the most commonly referenced solvent in published kisspeptin research protocols. Sterile water or PBS may also be used depending on the assay format.
How does Kisspeptin-10 differ from Kisspeptin-54? Kisspeptin-54 is the full-length precursor encoded by the KISS1 gene; kisspeptin-10 is the bioactive C-terminal decapeptide fragment that retains full GPR54 receptor potency and is the predominant form used in research.
Can this be used in cell culture experiments? Yes, when properly reconstituted and diluted under sterile conditions for in vitro applications including GPR54-expressing cell lines.